1-(2-Methoxyphenyl)piperazine → 2-Carbamoyl-7-{2-hydroxy-3-[4-(2-methoxyphenyl)piperazinyl]propoxy}benzofuran

참여 물질

반응 단계

There was suspended 1.2 g (0.005 mole) of 2-carbamoyl-7-(2,3-epoxypropoxy)benzofuran in 15 ml of ethanol, and thereto 1.1 g (0.0055 mole) of 1-(2-methoxyphenyl)piperazine was added. Thereafter, the mixture was refluxed with heating for 2 hours. After completion of the reaction, the solvent was distilled away from the reaction mixture under reduced pressure, and then the resultant residue was crystallized from chloroform and petroleum ether.

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