Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-((6-Methyl-3-pyridyl)methyl)-2-(nitroamino)-1H-pyrimidin-4-one → 2-[3-(Pyrid-2-ylamino)propylamino]-5-(6-methylpyrid-3-ylmethyl)-4-pyrimidone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-((6-Methyl-3-pyridyl)methyl)-2-(nitroamino)-1H-pyrimidin-4-one | HCID 3018360 | — |
| 반응물 | N-(3-aminopropyl)pyridin-2-amine | HCID 10606924 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 2-[3-(Pyrid-2-ylamino)propylamino]-5-(6-methylpyrid-3-ylmethyl)-4-pyrimidone | HCID 14397376 | 70% |
반응 단계
2-(3-Aminopropylamino)pyridine (1.74 g) and 2-nitroamino-5-(6-methylpyrid-3-ylmethyl)-4-pyrimidone (2.0 g) were heated together under reflux in pyridine (8 ml) for 22 hr. The mixture was stripped, the residue triturated with ether and then water (the pH of which was adjusted to 6.5 with dilute acetic acid) to give a white solid. Recrystallisation from isopropanol gave 2-[3-(pyrid-2-ylamino)propylamino]-5-(6-methylpyrid-3-ylmethyl)-4-pyrimidone, (1.87 g; 70%), m.p. 163°-165° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04652650 |
| 출처 데이터셋 | uspto-grants-1987_03 |
| ORD ID | ord-ace70d7ad007472a84da9b1bd14a0ac1 |
| 출처 메모 | uspto-grants-1987_03 |