Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Chloro-1-propyne → Methyl 2-hydroxy-4-propargyloxybenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Chloro-1-propyne | HCID 12221 | — |
| 반응물 | Methyl 2,4-Dihydroxybenzoate | HCID 16523 | — |
| 반응물 | Pyrazine-2,3-diamine | HCID 284161 | — |
| 반응물 | 2-Methoxy-4-[(prop-2-yn-1-yl)oxy]benzoic acid | HCID 13121460 | — |
| 생성물 | Methyl 2-hydroxy-4-propargyloxybenzoate | HCID 13121476 | — |
반응 단계
A mixture of 11 g of 2,3-diaminopyrazine (IIa), 20.6 g of 2-methoxy-4-propargyloxybenzoic acid [m.p. 142°; obtainable by reacting methyl 2,4-dihydroxybenzoate with propargyl chloride to give methyl 2-hydroxy-4-propargyloxybenzoate (m.p. 100°), reacting the latter with methyl iodide to give methyl 2-methoxy-4-propargyloxybenzoate (m.p. 88°), and hydrolysing the latter] and 300 ml of POCl3 is boiled for 2 hours. The mixture is evaporated to dryness, ice-water is added to the residue, and the mixture is rendered alkaline with K2CO3 solution. The precipitated 2-(2-methoxy-4-propargyloxyphenyl)-1,3,4,7-tetraazaindene is filtered off. M.p. 189°-190°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04654344 |
| 출처 데이터셋 | uspto-grants-1987_03 |
| ORD ID | ord-1d0fc1b72c2a41809c4454b901cd30b6 |
| 출처 메모 | uspto-grants-1987_03 |