Potassium Hydroxide → Bamaluzole

HRID 1906743

반응식

HRID 1906743 반응식
Cl[C:2]1[C:7]2[N:8]=[CH:9][N:10]([CH3:11])[C:6]=2[CH:5]=[CH:4][N:3]=1.[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][OH:16].[OH-].[K+]>C(#N)C>[Cl:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][O:16][C:2]1[C:7]2[N:8]=[CH:9][N:10]([CH3:11])[C:6]=2[CH:5]=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 288102-Chlorobenzyl alcoholHCID 9487924-chloro-1-methyl-1H-imidazo(4,5-c)pyridine

생성물 1

HCID 3086242Bamaluzole

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 7.5 g of 4-chloro-1-methyl-1H-imidazo(4,5-c)pyridine, 7.1 g of 2-chlorobenzyl alcohol, 3.3 g of KOH and 100 ml of acetonitrile is refluxed for 7 hours. The solvent is removed and the residue is worked up in the customary manner (water/methylene chloride) to give 4-o-Chlorobenzyloxy-1-methyl-1H-imidazo(4,5-c)pyridine, m.p. 132°-135°.

후처리

  1. temperatureis refluxed for 7 hours
  2. customThe solvent is removed

출처 및 근거

ORD 기록
ord-9c75251ce62041259494c3e9c8a4fb0a
출처 데이터셋
uspto-grants-1987_03
특허 번호
US04654350

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