Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Methylhydrazinecarbothioamide → N-Methyl-N-[3-[3-(methylamino)-1,2,4-triazolo[4,3-b]-pyridazin-6-yl]phenyl]propanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Methylhydrazinecarbothioamide | HCID 2723853 | — |
| 반응물 | N-methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide | HCID 14280298 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-Methyl-N-[3-[3-(methylamino)-1,2,4-triazolo[4,3-b]-pyridazin-6-yl]phenyl]propanamide | HCID 15595694 | 16% |
반응 단계
A solution of 5.0 g of N-methyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide and 3.8 g 4-methylthiosemicarbazide in 200 ml ethanol was refluxed for 18 hours. The mixture was then treated and the product chromatographed as described in Example 70. Recrystallization of the product from dichloromethane-hexane afforded 0.9 g yellow powder, mp 212°-213° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04654343 |
| 출처 데이터셋 | uspto-grants-1987_03 |
| ORD ID | ord-91e8ad14a3ac4252a44a26dc3ae9ec3a |
| 출처 메모 | uspto-grants-1987_03 |