Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thiosemicarbazide → N-Ethyl-N-[3-(3-amino-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]propanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thiosemicarbazide | HCID 2723789 | — |
| 반응물 | N-ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide | HCID 14280299 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-Ethyl-N-[3-(3-amino-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]propanamide | HCID 15595696 | 44.8% |
반응 단계
A solution of 5.0 g N-ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide and 3.2 g thiosemicarbazide in 200 ml ethanol was refluxed for 18 hours. The mixture was treated and the product chromatographed as described for Example 70. Recrystalization of the product from dichloromethane-hexane afforded 2.4 g yellow crystals, mp 199°-200° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04654343 |
| 출처 데이터셋 | uspto-grants-1987_03 |
| ORD ID | ord-2be52cf7f9bc4df9be7fe5307c8cc9e4 |
| 출처 메모 | uspto-grants-1987_03 |