Dihydroxyacetone → 1,3-Dibutyrin

HRID 1906914노트

반응식

HRID 1906914 반응식
[OH:1][CH2:2][C:3]([CH2:5][OH:6])=[O:4].[C:7](Cl)(=[O:11])[CH2:8][CH2:9][CH3:10]>N1C=CC=CC=1>[C:7]([O:1][CH2:2][CH:3]([OH:4])[CH2:5][O:6][C:7](=[O:11])[CH2:8][CH2:9][CH3:10])(=[O:11])[CH2:8][CH2:9][CH3:10]

참가 물질

4

반응물 2

HCID 670DihydroxyacetoneHCID 8855Butyryl chloride

생성물 1

HCID 1229201,3-Dibutyrin

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

By following the procedure of Example 1(a) and 1(b) using 13.05 g. of 1,3-dihydroxyacetone, 23.7 g. of pyridine and 31.1 g. of butyryl chloride, 17.9 g. of 1,3-dibutanoyloxy-2-propanol is obtained. The reaction of 12.2 g. of this material and 9.4 g. of valproyl chloride and 4.98 g. of pyridine as described in Example 1(c) yields an oil which is purified by chromatography as described in Example 3. The pure 1,3-dibutanoyl-2-valproyl-glyceride is eluted from the column with petroleum ether/ether (95:5); it is obtained in a yield of 9.1 g.; Rf 0.61 (petroleum ether/ether 3:1); mass spectrum m/e 316 (M+ -42).

출처 및 근거

ORD 기록
ord-0d533ae828c945839b89498cd6af0d14
출처 데이터셋
uspto-grants-1987_03
특허 번호
US04654370

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