Sodium Chloride → 3-(Methanesulfinyl)-1H-indole

HRID 1906932노트

반응식

HRID 1906932 반응식
S(OOS([O-])(=O)=O)([O-])(=O)=[O:2].[K+].[K+].[CH3:13][S:14][C:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[NH:17][CH:16]=1.[Cl-].[Na+]>O.CO>[CH3:13][S:14]([C:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[NH:17][CH:16]=1)=[O:2]

참가 물질

6

반응물 3

HCID 5234Sodium ChlorideHCID 24412Potassium PersulfateHCID 108882523-(methylthio)-1H-indole

생성물 1

HCID 130306043-(Methanesulfinyl)-1H-indole

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매2회

실험 절차

Potassium persulfate (KHSO5, 55 g, 179 mmol) in water (300 ml) was slowly added to a solution of 3-methylthioindole (29.3 g, 179 mmol) in methanol (300 ml) cooled in a ice bath. One half hour after the addition was completed, water was added, the solution was saturated with sodium chloride and the product was extracted into chloroform. The extract was dried, evaporated in vacuo and the residue was crystallized from chloroform-ethyl acetate to give the title product.

후처리

  1. temperaturecooled in a ice bath
  2. additionOne half hour after the addition
  3. extractionthe product was extracted into chloroform
  4. customThe extract was dried
  5. customevaporated in vacuo
  6. customthe residue was crystallized from chloroform-ethyl acetate

출처 및 근거

ORD 기록
ord-ab3cf6f5e7554f3a9cf5917d310e0113
출처 데이터셋
uspto-grants-1987_03
특허 번호
US04654360

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