tert-Butyl hydroperoxide → (trans)-3-(6-Phenyl-1,3,5-hexatriynyl)oxiranemethanol

HRID 1906978노트

반응식

HRID 1906978 반응식
[C:1]1([C:7]#[C:8][C:9]#[C:10][C:11]#[C:12]/[CH:13]=[CH:14]/[CH2:15][OH:16])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([O:21]O)(C)(C)C>C1C=CC=CC=1.C/C(/O)=C\C(C)=O.C/C(/O)=C\C(C)=O.O=[V]>[C:1]1([C:7]#[C:8][C:9]#[C:10][C:11]#[C:12][C@@H:13]2[O:21][C@H:14]2[CH2:15][OH:16])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 2

HCID 6410tert-Butyl hydroperoxide2회HCID 13632676(E)-9-phenyl-2-nonen-4,6,8-triyn-1-ol

생성물 1

HCID 86740798(trans)-3-(6-Phenyl-1,3,5-hexatriynyl)oxiranemethanol

시약·촉매·용매 2

HCID 16217092Bis(2,4-pentanedionato)vanadium(IV) Oxide촉매HCID 241Benzene용매2회

실험 절차

To a stirred solution of 103 mg (0.50 mmole) of (E)-9-phenyl-2-nonen-4,6,8-triyn-1-ol in 20 ml of dry benzene was added 5 mg of vanadyl acetylacetonate and 0.095 ml (0.50 mmole) of a 5.24M solution of t-butylhydroperoxide in benzene. Further 0.095 ml portions of t-butyl hydroperoxide solution were added after 2 hours and 31/2 hours. After stirring for 18 hours, the benzene solution was concentrated and purified via preparative thin layer chromatography (Analtech, 2 mm, silica gel; ether-hexane 1:1) to afford 59 mg of the title compound, melting point 68°-70° C.

후처리

  1. custom2 hours
  2. concentrationthe benzene solution was concentrated
  3. custompurified via preparative thin layer chromatography (Analtech, 2 mm, silica gel; ether-hexane 1:1)

출처 및 근거

ORD 기록
ord-4e2500f9966b4b28a88bbd904c4e53b2
출처 데이터셋
uspto-grants-1987_03
특허 번호
US04654426

반응 노트

불러오는 중…