HCID 178418361, 화합물 → HCID 178507347, 화합물

HRID 1907221노트

반응식

HRID 1907221 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][C:11]2[NH:10][CH:9]=[C:8]3[C:14](=[O:23])[N:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[N:16]=[C:7]3[C:6]=2[CH:5]=1)([O-])=O.[H][H]>CO.[Pd]>[NH2:1][C:4]1[CH:13]=[CH:12][C:11]2[NH:10][CH:9]=[C:8]3[C:14](=[O:23])[N:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[N:16]=[C:7]3[C:6]=2[CH:5]=1

참가 물질

5

반응물 2

HCID 178418361HCID 178418361, 화합물HCID 178515216HCID 178515216, 화합물

생성물 1

HCID 178507347HCID 178507347, 화합물수율 87%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 5a in methanol were added catalytic amounts of Pd on carbon. Reaction mixture was stirred at 20 psi of hydrogen overnight. Solid was filtered off and methanol was removed in vacuo to afford 8-amino-2-phenyl-2,5-dihydro-pyrazolo-(4,3-c) quinolin-3-one in 87% yield. 1H-NMR (DMSO-d6) δ (ppm): 6.92 (1H, dd, J=8.79, 2.47 Hz), 7.13 (1H, m), 7.28 (1H, d, J=2.47 Hz), 7.43 (3H, m), 8.20 (2H, dd, J=7.69, 1.10 Hz), 8.44 (1H, d, J=6.59 Hz). m/z 277.3 (MH+).

후처리

  1. customReaction mixture
  2. filtrationSolid was filtered off
  3. custommethanol was removed in vacuo

출처 및 근거

ORD 기록
ord-2ee4e6fcee0c40318b3c188e7597515d
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598159B2

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