Trifluoroacetic acid → HCID 86620425, 화합물

HRID 1907697노트

반응식

HRID 1907697 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[N:16]=[CH:15][C:14](/[CH:17]=[CH:18]/[C:19]([O:21]C(C)(C)C)=[O:20])=[CH:13][CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29]>C(Cl)Cl>[F:26][C:27]([F:32])([F:31])[C:28]([OH:30])=[O:29].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[N:16]=[CH:15][C:14](/[CH:17]=[CH:18]/[C:19]([OH:21])=[O:20])=[CH:13][CH:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 71089237HCID 71089237, 화합물

생성물 1

HCID 86620425HCID 86620425, 화합물수율 92%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of tert-butyl ester 39 (0.45 g, 1.3 mmol) in DCM (5 mL) was added neat trifluoroacetic acid (1.7 mL). The reaction was allowed to stir at room temperature for 18 h then concentrated; the residue was triturated with diethyl ether, to give title compound 40 (0.376 g, 92% yield).

후처리

  1. concentrationthen concentrated
  2. customthe residue was triturated with diethyl ether

출처 및 근거

ORD 기록
ord-bc55c2b68a9c4f659d8c0a1032c8756f
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598168B2

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