Morpholine → HCID 53944659, 화합물

HRID 1907706노트

반응식

HRID 1907706 반응식
CS([C:5]1[N:10]=[CH:9][C:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:7][N:6]=1)(=O)=O.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>COCCOC.C(Cl)Cl>[O:19]1[CH2:20][CH2:21][N:16]([C:5]2[N:10]=[CH:9][C:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:7][N:6]=2)[CH2:17][CH2:18]1

참가 물질

5

반응물 2

HCID 8083MorpholineHCID 254889Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate

생성물 1

HCID 53944659HCID 53944659, 화합물수율 108%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 80711,2-Dimethoxyethane용매

실험 절차

A solution of sulfone 121 (0.184 g, 0.80 mmol) in ethyleneglycol dimethylether (5 mL) was treated with neat morpholine (0.3 mL, 3.4 mmol) and the mixture was stirred at room temperature for 48 h. The reaction mixture was then diluted with DCM and washed with saturated NaHCO3 in brine, dried over MgSO4, filtered, concentrated and stored under vacuum to give intermediate 122 (0.205 g, >99% yield).

후처리

  1. washwashed with saturated NaHCO3 in brine
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-dcd232c1eff14adbb87198f411184f79
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598168B2

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