3-(2-Bromoacetyl)pyridine → HCID 59737476, 화합물

HRID 1907768노트

반응식

HRID 1907768 반응식
[NH:1]([C:5]1[CH:15]=[CH:14][C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:7][CH:6]=1)[C:2]([NH2:4])=[S:3].Br[CH2:17][C:18]([C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1)=O>O>[N:22]1[CH:23]=[CH:24][CH:25]=[C:20]([C:18]2[N:4]=[C:2]([NH:1][C:5]3[CH:15]=[CH:14][C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:7][CH:6]=3)[S:3][CH:17]=2)[CH:21]=1

참가 물질

4

반응물 2

HCID 1514083-(2-Bromoacetyl)pyridineHCID 28088481-(4-Ethoxycarbonylphenyl)-2-thiourea

생성물 1

HCID 59737476HCID 59737476, 화합물수율 166.2%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

Ethyl 4-thioureidobenzoate (209 mg, 0.935 mmol) was added to a warm solution (50° C.) of 2-bromo-1-(pyridin-3-yl)ethanone (250 mg, 0.88 mmol) in water (5 mL) and stirred at 50° C. for 5 h. The precipitated was filtered out to afford the title compound 428 as a yellow solid (476 mg, wet) which was used without further purification.

후처리

  1. filtrationThe precipitated was filtered out

출처 및 근거

ORD 기록
ord-a7a2d34652254ee7a28861f766b5f591
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598168B2

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