Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diphenylsilane → 4-(4-Bromo-3-fluorobenzyl)morpholine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diphenylsilane | HCID 69888 | — |
| 반응물 | (4-Bromo-3-fluorophenyl)(morpholin-4-yl)methanone | HCID 48474115 | — |
| 촉매 | Carbonyltris(triphenylphosphine)rhodium(I)hydride | HCID 53249357 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-(4-Bromo-3-fluorobenzyl)morpholine | HCID 53417818 | — |
반응 단계
A 250 ml flask was charged with (4-bromo-3-fluorophenyl)(morpholino)methanone (4.569 g, 15.86 mmol) and dissolved in 16 mL of THF. Diphenylsilane (6.2 ml, 33.4 mmol) was added followed by carbonyltris(triphenylphosphine)rhodium(I)hydride (100 mg, 0.109 mmol) and the reaction stirred at room temperature for 20 hours.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08598169B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-7f048c54528c4de8b280552f6360c4a3 |
| 출처 메모 | uspto-grants-2013_12 |