Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-1-(4-fluorophenyl)ethanone → 2-Amino-1-(4-fluorophenyl)ethan-1-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-1-(4-fluorophenyl)ethanone | HCID 1581177 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-Amino-1-(4-fluorophenyl)ethan-1-ol | HCID 9827 | 100% |
반응 단계
To a solution consisting of 2-amino-1-(4-fluoro-phenyl)-ethanone (150 mg, 0.9 mmol) and MeOH (5 mL) was added NaBH4 (97 mg, 2.6 mmol). The mixture was stirred at rt for 45 min and then concentrated to dryness. The residue was diluted with EtOAc and washed with a satd. NH4Cl solution before drying (Na2SO4), and concentrating to give 2-amino-1-(4-fluoro-phenyl)-ethanol (139 mg, 100%) which was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08598202B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-3de15211aafd4142a970ccbc6622e103 |
| 출처 메모 | uspto-grants-2013_12 |