HCID 66599715, 화합물 → HCID 66599747, 화합물
반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[CH:14]=[C:13]([CH:15]([C:17]2[N:18]([CH2:28][O:29][CH2:30][CH2:31][Si:32]([CH3:35])([CH3:34])[CH3:33])[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH3:27])[CH:26]=3)=[CH:20][N:21]=2)[OH:16])[CH:12]=[CH:11][N:10]=1>ClCCl.[O-2].[O-2].[Mn+4]>[F:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[C:3]=1[C:9]1[CH:14]=[C:13]([C:15]([C:17]2[N:18]([CH2:28][O:29][CH2:30][CH2:31][Si:32]([CH3:35])([CH3:34])[CH3:33])[C:19]([C:22]3[CH:23]=[N:24][N:25]([CH3:27])[CH:26]=3)=[CH:20][N:21]=2)=[O:16])[CH:12]=[CH:11][N:10]=1참가 물질
4
실험 절차
To a stirred solution of [2-(2,6-difluoro-phenyl)-pyridin-4-yl]-[5-(1-methyl-1H-pyrazol-4-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]methanol (78 mg, 0.157 mmol, as a mixture of two regioisomers) in dichloromethane (3 mL) at room temperature was added manganese dioxide (273 mg, 3.14 mmol). The mixture was stirred at room temperature overnight before it was filtered and concentrated in vacuo. Purification by SiO2 chromatography provided [2-(2,6-difluoro-phenyl)-pyridin-4-yl]-[5-(1-methyl-1H-pyrazol-4-yl)-1-(2 trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-methanone (75 mg, as a mixture of two regioisomers).