Water → (R)-benzyl 1-cyanoethylcarbamate
반응식
[NH2:1][C:2](=O)[C@H:3]([NH:5][C:6](=[O:15])[O:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:4].ClC1N=C(Cl)N=C(Cl)N=1.O>CN(C)C=O>[C:2]([C@H:3]([NH:5][C:6](=[O:15])[O:7][CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)[CH3:4])#[N:1]참가 물질
5
실험 절차
To a solution of benzyl [(1R)-2-amino-1-methyl-2-oxoethyl]carbamate (10 g, 45 mmol) in 50 mL of N,N-dimethylformamide was added 2,4,6-trichloro-1,3,5-triazine (4.15 g, 22.5 mmol). After 2 h, 100 mL of water was added and the mixture was filtered. The solids were washed with 100 mL aqueous sodium bicarbonate (2×) and dried under vacuum to give pure benzyl [(1R)-1-cyanoethyl]carbamate (7.2 g). MS 205.2 ((M+1).
후처리
- filtrationthe mixture was filtered
- washThe solids were washed with 100 mL aqueous sodium bicarbonate (2×)
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-b98e1b25f55f41b8a66792fecb5040f4
- 출처 데이터셋
- uspto-grants-2013_12
- 특허 번호
- US08598209B2
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