Cyclopropaneacetic acid → HCID 178520145, 화합물

HRID 1909365노트

반응식

Cl.[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:24][CH2:23][C@H:22]([NH2:25])[CH2:21][CH2:20]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1.[CH:26]1([CH2:29][C:30](O)=[O:31])[CH2:28][CH2:27]1>>[O:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C@H:19]4[CH2:20][CH2:21][C@H:22]([NH:25][C:30](=[O:31])[CH2:29][CH:26]5[CH2:28][CH2:27]5)[CH2:23][CH2:24]4)[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3]1

참가 물질

반응물 2

HCID 138440Cyclopropaneacetic acid

HCID 178479251HCID 178479251, 화합물2회

생성물 1

HCID 178520145HCID 178520145, 화합물

실험 절차

The title compound, white solid (22.4 mg, 67.9%), MS (ISP) m/z=413.5 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperidin-1-yl)-ethyl]-cyclohexylamine hydrochloride (intermediate A) (29.4 mg, 0.080 mmol) and 2-cyclopropylacetic acid.

출처 및 근거

ORD 기록: ord-e65d356b57d64c47a0fc1521438418f7
출처 데이터셋: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08598357B2

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