Thionyl Chloride → 5-Bromo-7-(chloromethyl)-2,2-dimethyl-2,3-dihydrobenzofuran

HRID 1909560노트

반응식

HRID 1909560 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH2:13]O)[C:5]2[O:9][C:8]([CH3:11])([CH3:10])[CH2:7][C:6]=2[CH:12]=1.S(Cl)([Cl:17])=O>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]([CH2:13][Cl:17])[C:5]2[O:9][C:8]([CH3:11])([CH3:10])[CH2:7][C:6]=2[CH:12]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 58566787(5-Bromo-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)methanol

생성물 1

HCID 585664675-Bromo-7-(chloromethyl)-2,2-dimethyl-2,3-dihydrobenzofuran

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (5-bromo-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)methanol (669) (390 mg, 1.51 mmol) in dichloromethane (15 mL) was added thionyl chloride (0.56 mL, 7.58 mmol). The reaction was stirred at room temperature for 2 hours and then concentrated to afford 5-bromo-7-(chloromethyl)-2,2-dimethyl-2,3-dihydrobenzofuran (670).

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-71a4de77d1e74887a64f81db0d2e92ff
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598374B2

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