4-Amino-2,2,6,6-tetramethylpiperidine → 6-chloro-N-(3-{8-(2,6-difluorophenyl)-7-oxo-2-[(2,2,6,6-tetramethyl-4-piperidinyl)amino]-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl}-4-methylphenyl)-3-pyridinecarboxamide

반응식

[CH3:41][C:42]1([CH3:51])[NH:43][C:44]([CH3:49])([CH3:50])[CH2:45][CH:46]([NH2:48])[CH2:47]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8](=[O:9])[NH:10][c:11]2[cH:12][c:13](-[c:18]3[c:19]4[c:20]([n:21][c:22]([S:24]([CH3:25])(=[O:26])=[O:27])[n:23]3)[n:28](-[c:33]3[c:34]([F:40])[cH:35][cH:36][cH:37][c:38]3[F:39])[c:29](=[O:32])[cH:30][cH:31]4)[c:14]([CH3:17])[cH:15][cH:16]2)[cH:6][n:7]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8](=[O:9])[NH:10][c:11]2[cH:12][c:13](-[c:18]3[c:19]4[c:20]([n:21][c:22]([NH:48][CH:46]5[CH2:45][C:44]([CH3:49])([CH3:50])[NH:43][C:42]([CH3:41])([CH3:51])[CH2:47]5)[n:23]3)[n:28](-[c:33]3[c:34]([F:40])[cH:35][cH:36][cH:37][c:38]3[F:39])[c:29](=[O:32])[cH:30][cH:31]4)[c:14]([CH3:17])[cH:15][cH:16]2)[cH:6][n:7]1