Boron tribromide → 4-(4-Hydroxyphenoxy)benzonitrile

HRID 1909627노트

반응식

HRID 1909627 반응식
B(Br)(Br)Br.C[O:6][C:7]1[CH:21]=[CH:20][C:10]([O:11][C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=2)=[CH:9][CH:8]=1>ClCCl>[OH:6][C:7]1[CH:21]=[CH:20][C:10]([O:11][C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=2)=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 14902794-(4-methoxyphenoxy)benzonitrile

생성물 1

HCID 45227124-(4-Hydroxyphenoxy)benzonitrile수율 74.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Following the general procedure for Example 11 (step 2), boron tribromide (1.0 M solution in dichloromethane, 5.73 mL, 5.73 mmol) was added to the product from step 1 (0.43 g, 1.91 mmol) in dichloromethane (10 mL) to afford the title compound (0.30 g, 74%) as an off-white solid.

출처 및 근거

ORD 기록
ord-4d58eeab11d94a2ab87376dc0eef6f03
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598359B2

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