6-Chloropiperonyl chloride → (r)-2-[4-(6-Chloro-benzo[1,3]dioxol-5-ylmethoxy)phenoxymethyl]pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 1909730

반응식

HRID 1909730 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:22][C:23]1[C:31]([CH2:32]Cl)=[CH:30][C:26]2[O:27][CH2:28][O:29][C:25]=2[CH:24]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C@@H:9]1[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:32][C:31]2[C:23]([Cl:22])=[CH:24][C:25]3[O:29][CH2:28][O:27][C:26]=3[CH:30]=2)=[CH:17][CH:16]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 901136-Chloropiperonyl chlorideHCID 68999591(R)-2-(4-Hydroxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 68998670(r)-2-[4-(6-Chloro-benzo[1,3]dioxol-5-ylmethoxy)phenoxymethyl]pyrrolidine-1-carboxylic acid tert-butyl ester수율 40%

실험 절차

Followed the same procedure as that of step 2 in Example 91 with the use of (R)-2-(4-hydroxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (150 mg, 0.5 mmol) and 5-chloro-6-chloromethyl-benzo[1,3]dioxole (125 mg, 0.6 mmol) to afford the title product (80 mg, 40% yield).

출처 및 근거

ORD 기록
ord-388617f2bb4e43f89427c6f3fdb08f10
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598359B2

연결된 노트

불러오는 중…