Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Monobenzone → 3-(4-Benzyloxy-phenoxy)-pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Monobenzone | HCID 7638 | — |
| 반응물 | Diglyme | HCID 8150 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 3-Iodopyridine | HCID 70714 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 3-(4-Benzyloxy-phenoxy)-pyridine | HCID 68999185 | 26.2% |
반응 단계
To a solution of p-benzyloxyphenol (550 mg, 2.754 mmol), Cs2CO3 (1.795 g, 5.509 mmol), 3-iodo pyridine (850 mg, 4.14 mmol) in anhydrous dioxane (15 ml) under N2 was added diglyme (38.42 mg, 0.275 mmol). After stirring for 10 min, CuI (19.38 mg, 0.102 mmol) was added and the reaction mixture was kept in a shaker at 85° C. overnight. The mixture was poured into EtOAc and water, the organic layer was dried over Na2SO4, and concentrated. Silica gel flash chromatography using EtOAc/Hexane gave the title compound (200 mg, 17%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08598359B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-f25cd57d69554f58ab2905fc224187d6 |
| 출처 메모 | uspto-grants-2013_12 |