Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1909885생성일: 2026년 10월 26일
Methyl indole-7-carboxylate → Methyl 1-((1-phenylpiperidin-4-yl)methyl)-1H-indole-7-carboxylate
https://huagongshe.com/reaction/1909885
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl indole-7-carboxylate | HCID 676694 | — |
| 반응물 | Cyanomethylenetributylphosphorane | HCID 4622928 | — |
| 반응물 | (1-Phenylpiperidin-4-yl)methanol | HCID 17768191 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Methyl 1-((1-phenylpiperidin-4-yl)methyl)-1H-indole-7-carboxylate | HCID 58307013 | 13.9% |
반응 단계
To a mixture of (1-phenylpiperidin-4-yl)methanol (958 mg), methyl 1H-indole-7-carboxylate (590 mg), and toluene (20 mL) was added (tributylphosphoranylidene)acetonitrile (1.0 g) at room temperature. The mixture was stirred at 100° C. for 1 day. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain methyl 1-[(1-phenylpiperidin-4-yl)methyl]-1H-indole-7-carboxylate (163 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08598355B2 |
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| 출처 데이터셋 | uspto-grants-2013_12 |
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| ORD ID | ord-a42d8d0904a242ed9ef58cd3e12324b9 |
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| 출처 메모 | uspto-grants-2013_12 |
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