Ammonium Hydroxide → 5-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

반응식

[Br:1][C:2]1[C:10]2[C:9](Cl)=[N:8][CH:7]=[N:6][C:5]=2[N:4]([CH3:12])[CH:3]=1.[OH-].[NH4+:14]>>[Br:1][C:2]1[C:10]2[C:9]([NH2:14])=[N:8][CH:7]=[N:6][C:5]=2[N:4]([CH3:12])[CH:3]=1

참가 물질

반응물 2

HCID 14923Ammonium Hydroxide

HCID 665451605-Bromo-4-chloro-7-methyl-7H-pyrrolo(2,3-d)pyrimidine

생성물 1

HCID 665609385-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine수율 79.8%

반응 조건

온도: 100 °C

실험 절차

A suspension of 5-bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (17 g, 69.0 mmol) in ammonium hydroxide (150 mL, 3852 mmol) was stirred for 2 days at 100° C. in a sealed vessel. The reaction was allowed to cool to room temperature and filtered. The collected solid was washed with Et2O to afford the product 5-bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (12.5 g) as a white solid.

후처리

temperatureto cool to room temperature
filtrationfiltered
washThe collected solid was washed with Et2O

출처 및 근거

ORD 기록: ord-0d37edfcb1604732885826ec3915d32b
출처 데이터셋: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08598156B2

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