참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonium Hydroxide | HCID 14923 | — |
| 반응물 | 5-Bromo-4-chlorothieno[2,3-d]pyrimidine | HCID 45480299 | — |
| 생성물 | 5-Bromothieno[2,3-D]pyrimidin-4-amine | HCID 66823898 | 86.3% |
반응 단계
A suspension of 5-bromo-4-chlorothieno[2,3-d]pyrimidine (1 g, 4.01 mmol) in concentrated aqueous ammonium hydroxide (150 mL, 3852 mmol) was stirred overnight at 90° C. in a sealed vessel. The reaction was allowed to cool to room temperature and filtered. The white solid in the filter was air dried to afford 5-bromothieno[2,3-d]pyrimidin-4-amine (796 mg). LC/MS (ES) m/z=387.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08598156B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_12 |
|---|
| ORD ID | ord-443a428a30dd4020bd5d2bdeacc9c33a |
|---|
| 출처 메모 | uspto-grants-2013_12 |
|---|
