Ammonium Hydroxide → 5-bromo-7-(3-oxetanyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

HRID 1910064노트

반응식

HRID 1910064 반응식
[Br:1][C:2]1[C:10]2[C:9](Cl)=[N:8][CH:7]=[N:6][C:5]=2[N:4]([CH:12]2[CH2:15][O:14][CH2:13]2)[CH:3]=1.[OH-].[NH4+:17]>>[Br:1][C:2]1[C:10]2[C:9]([NH2:17])=[N:8][CH:7]=[N:6][C:5]=2[N:4]([CH:12]2[CH2:15][O:14][CH2:13]2)[CH:3]=1

참가 물질

3

반응물 2

HCID 14923Ammonium HydroxideHCID 866636865-bromo-4-chloro-7-(3-oxetanyl)-7H-pyrrolo[2,3-d]pyrimidine

생성물 1

HCID 668240635-bromo-7-(3-oxetanyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine수율 61.5%

반응 조건

온도
85 °C

실험 절차

To 5-bromo-4-chloro-7-(3-oxetanyl)-7H-pyrrolo[2,3-d]pyrimidine (185 mg, 0.641 mmol) was added ammonium hydroxide (24.97 μl, 0.641 mmol) in a 25 ml sealable vial and heated at 85° C. over 24 hr. The solid was isolated by filtration and washed with water (5 mL) and dried to give 5-bromo-7-(3-oxetanyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (106 mg), which was used without further purification.

후처리

  1. customThe solid was isolated by filtration
  2. washwashed with water (5 mL)
  3. customdried

출처 및 근거

ORD 기록
ord-51cfc3000dbb4fd08298e36cd8c7a6eb
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598156B2

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