Methanol → Methyl 2-amino-3-(3,5-difluorophenyl)propanoate hydrochloride

HRID 1910112노트

반응식

HRID 1910112 반응식
[NH2:1][CH:2]([CH2:6][C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[C:9]([F:14])[CH:8]=1)[C:3]([OH:5])=[O:4].S(Cl)([Cl:17])=O.[CH3:19]O>>[ClH:17].[CH3:19][O:4][C:3](=[O:5])[CH:2]([NH2:1])[CH2:6][C:7]1[CH:8]=[C:9]([F:14])[CH:10]=[C:11]([F:13])[CH:12]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 27370453,5-Difluorophenylalanine

생성물 1

HCID 66940454Methyl 2-amino-3-(3,5-difluorophenyl)propanoate hydrochloride수율 100%

실험 절차

1.05 g (5.0 mmol) of 2-amino-3-(3,5-difluoro-phenyl)-propionic acid (1.05 g, 5 mmol) was dissolved in 30.0 mL of MeOH, then 1.0 mL of thionyl chloride was added dropwise. The mixture was refluxed overnight. Evaporation of the solvent yielded the solid 2-Amino-3-(3,5-difluoro-phenyl)-propionic acid methyl ester HCl salt (1.26 g, 100%), and it was used directly in the next step.

후처리

  1. temperatureThe mixture was refluxed overnight
  2. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-30377a75f2f14d67be8ed123f387b27e
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598353B2

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