Cyanogen Bromide → HCID 178508200, 화합물

HRID 1910272노트

반응식

HRID 1910272 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[C:6]([NH2:11])[CH:5]=1)([O-:3])=[O:2].Br[C:13]#[N:14]>C(O)C.O>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]2[NH:10][C:13]([NH2:14])=[N:11][C:6]=2[CH:5]=1)([O-:3])=[O:2]

참가 물질

5

반응물 2

HCID 10476Cyanogen BromideHCID 51117914-Nitro-1,2-phenylenediamine

생성물 1

HCID 178508200HCID 178508200, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

7.6 g (50 mmol) of 4-nitro-ortho-phenylenediamine was dissolved were dissolved in 100 mL of ethanol and 20 mL of H2O. 7.9 g (75 mmol) of BrCN was added in one portion to this stirring solution, and the resulting mixture was heated under reflux for 1.0 h. The reaction mixture was cooled to room temperature, concentrated to 20 mL then neutralized with saturated NaHCO3 solution to pH 8, and resulting solid 5-nitro-1H-benzoimidazol-2-ylamine collected via filtration was used directly in the next step without further purification.

후처리

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 1.0 h
  3. concentrationconcentrated to 20 mL

출처 및 근거

ORD 기록
ord-3ea16703b6f340cea4d921082031c3ec
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08598353B2

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