2-Bromo-4'-methylacetophenone → HCID 86672938, 화합물

HRID 1910500

반응식

HRID 1910500 반응식
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([C:9]([O:11][CH:12]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=1)=[O:10])[CH2:2]2.[Br:27][CH2:28][C:29]([C:31]1[CH:36]=[CH:35][C:34]([CH3:37])=[CH:33][CH:32]=1)=[O:30]>C(#N)C>[Br-:27].[F:26][C:22]1[CH:21]=[C:20]([CH:12]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=2)[O:11][C:9]([CH:3]2[CH:4]3[CH2:5][CH2:6][N+:1]([CH2:28][C:29](=[O:30])[C:31]4[CH:36]=[CH:35][C:34]([CH3:37])=[CH:33][CH:32]=4)([CH2:8][CH2:7]3)[CH2:2]2)=[O:10])[CH:25]=[CH:24][CH:23]=1

참가 물질

4

반응물 2

HCID 692722-Bromo-4'-methylacetophenoneHCID 70925896Bis(3-fluorophenyl)methyl quinuclidine-3-carboxylate

생성물 1

HCID 86672938HCID 86672938, 화합물수율 76.4%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Bis(3-fluorophenyl)methyl quinuclidine-3-carboxylate (95 mg, 0.27 mmol, prepared as in example 4) and 2-bromo-1-p-tolylethanone (62.3 mg, 0.29 mmol) were dissolved in acetonitrile (10 ml) and stirred at room temperature overnight. The solvent was evaporated, and the residue was triturated with Et2O/EtOAc (1/1) and recovered by suction filtration to obtain 3-((bis(3-fluorophenyl)methoxy)carbonyl)-1-(2-oxo-2-p-tolylethyl)-1-azoniabicyclo[2.2.2]octane bromide (117.6 mg, racemic mixture).

후처리

  1. customThe solvent was evaporated
  2. customthe residue was triturated with Et2O/EtOAc (1/1)
  3. filtrationrecovered by suction filtration

출처 및 근거

ORD 기록
ord-c4fbf7cdd89f410fb32428cf34d866fb
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08604015B2

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