tert-Butyl chloroacetate → HCID 70673630, 화합물

HRID 1910501

반응식

HRID 1910501 반응식
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([C:9]([O:11][CH:12]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=1)=[O:10])[CH2:2]2.[Cl:27][CH2:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30]>C(#N)C>[Cl-:27].[F:26][C:22]1[CH:21]=[C:20]([CH:12]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=2)[O:11][C:9]([CH:3]2[CH:4]3[CH2:5][CH2:6][N+:1]([CH2:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])([CH2:8][CH2:7]3)[CH2:2]2)=[O:10])[CH:25]=[CH:24][CH:23]=1

참가 물질

4

반응물 2

HCID 66052tert-Butyl chloroacetate2회HCID 70925896Bis(3-fluorophenyl)methyl quinuclidine-3-carboxylate

생성물 1

HCID 70673630HCID 70673630, 화합물수율 41.7%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Bis(3-fluorophenyl)methyl quinuclidine-3-carboxylate (70 mg, 0.20 mmol, prepared as in example 4) and tert-butyl 2-chloroacetate (31 μl, 0.21 mmol) were dissolved in acetonitrile (3 ml) and stirred at room temperature overnight. Tert-butyl 2-chloroacetate (28 μl, 0.20 mmol) was added again, and the mixture was stirred for additional 24 hours. Acetonitrile was evaporated, and the resulting crude compound was triturated from Et2O and filtered to obtain 3-((bis(3-fluorophenyl)methoxy)carbonyl)-1-(2-tert-butoxy-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane chloride (42.4 mg, racemic mixture).

후처리

  1. stirringthe mixture was stirred for additional 24 hours
  2. customAcetonitrile was evaporated
  3. customthe resulting crude compound was triturated from Et2O
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-3d9eb796f2da440c93358be503ab396d
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08604015B2

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