Formic Acid → HCID 20116475, 화합물

HRID 1910768노트

반응식

HRID 1910768 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH:15](O)=O>C=O>[CH3:15][N:10]([CH2:11][C:12]([OH:14])=[O:13])[C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 284Formic AcidHCID 12095Glycine, N-(4-nitrophenyl)-

생성물 1

HCID 20116475HCID 20116475, 화합물수율 86%

시약·촉매·용매 1

HCID 712Formaldehyde용매

실험 절차

A solution of (4-nitro-phenylamino)-acetic acid (1.3 g, 6.6 mmol) in formic acid (5 mL) and formaldehyde (5 mL) was heated at reflux overnight. The mixture was concentrated in vacuo and 1N hydrochloric acid added to the residue giving a pH ˜3. The mixture was extracted with ethyl acetate then the organic phase was washed with water and brine. Concentration in vacuo afforded [methyl-(4-nitro-phenyl)-amino]-acetic acid (1.2 g, 86%) as a yellow solid.

후처리

  1. temperatureat reflux overnight
  2. concentrationThe mixture was concentrated in vacuo and 1N hydrochloric acid
  3. additionadded to the residue
  4. customgiving a pH ˜3
  5. extractionThe mixture was extracted with ethyl acetate
  6. washthe organic phase was washed with water and brine
  7. concentrationConcentration in vacuo

출처 및 근거

ORD 기록
ord-62628ced33c44bd5aa2bf325b5abea16
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08604029B2

반응 노트

불러오는 중…