Hydrochloric Acid → 4,6-Dimethyl-2(1H)-pyrimidinone hydrochloride

HRID 1910805

반응식

HRID 1910805 반응식
[C:1]([CH2:4][C:5](=O)[CH3:6])(=O)[CH3:2].[NH2:8][C:9]([NH2:11])=[O:10].[ClH:12]>C(O)C>[ClH:12].[CH3:2][C:1]1[CH:4]=[C:5]([CH3:6])[NH:11][C:9](=[O:10])[N:8]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 1176UreaHCID 31261Acetylacetone

생성물 1

HCID 123431664,6-Dimethyl-2(1H)-pyrimidinone hydrochloride수율 55%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
0 °C

실험 절차

To a mixture of acetyl acetone (4.0 g, 40.0 mmol) and urea (2.0 g, 33.3 mmol) in ethanol (40 mL) was added concentrated HCl (10 mL) and stirred at reflux for 3 h. The reaction mixture was cooled to 0° C. and filtered; the colourless solid was washed thoroughly with ice cold ethanol then ether and dried under vacuum to afford 4,6-dimethyl-1H-pyrimidin-2-one hydrochloride (3.5 g, 55%) as a solid.

후처리

  1. temperatureat reflux for 3 h
  2. filtrationfiltered
  3. washthe colourless solid was washed thoroughly with ice cold ethanol
  4. dry with materialether and dried under vacuum

출처 및 근거

ORD 기록
ord-491904216b374f63a45fd8b8a8d40266
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08604029B2

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