1-(2-Cyclopent-1-enyl-2-oxo-ethyl)-2-methyl-pyridinium bromide salt → 1-(2-Cyclopentyl-2-oxo-ethyl)-2-methyl-pyridinium bromide salt

HRID 1910834노트

반응식

HRID 1910834 반응식
[Br-:1].[C:2]1([C:7](=[O:16])[CH2:8][N+:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:15])[CH2:6][CH2:5][CH2:4][CH:3]=1>CO.[Pd]>[Br-:1].[CH:2]1([C:7](=[O:16])[CH2:8][N+:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:15])[CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

4

반응물 1

HCID 866395941-(2-Cyclopent-1-enyl-2-oxo-ethyl)-2-methyl-pyridinium bromide salt

생성물 1

HCID 866395921-(2-Cyclopentyl-2-oxo-ethyl)-2-methyl-pyridinium bromide salt수율 93%

시약·촉매·용매 2

HCID 23938Palladium촉매2회HCID 887Methanol용매

실험 절차

1-(2-Cyclopent-1-enyl-2-oxo-ethyl)-2-methyl-pyridinium bromide salt (3.65 g, 12.94 mmol) was dissolved in methanol (25 mL) and hydrogenated over 10% palladium on carbon (180 mg). After completion of the reaction the Pd/C was removed by filtration through celite, washing twice with methanol. Concentration of the filtrate afforded 1-(2-cyclopentyl-2-oxo-ethyl)-2-methyl-pyridinium bromide salt (3.4 g, 93%).

후처리

  1. customwas removed by filtration through celite
  2. washwashing twice with methanol

출처 및 근거

ORD 기록
ord-0d8cff0035894c989d0565b86bdecb82
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08604029B2

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