Oxalyl chloride → 2-oxo-2-(2-phenylindolizin-3-yl)acetyl Chloride

HRID 1910837노트

반응식

HRID 1910837 반응식
[C:1]([Cl:6])(=[O:5])[C:2](Cl)=[O:3].[C:7]1([C:13]2[CH:14]=[C:15]3[N:20]([CH:21]=2)[CH:19]=[CH:18][CH:17]=[CH:16]3)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C1(C)C=CC=CC=1.C1COCC1>[O:3]=[C:2]([C:21]1[N:20]2[C:15]([CH:16]=[CH:17][CH:18]=[CH:19]2)=[CH:14][C:13]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:1]([Cl:6])=[O:5]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 961282-Phenylindolizine

생성물 1

HCID 50082602-oxo-2-(2-phenylindolizin-3-yl)acetyl Chloride수율 80%

시약·촉매·용매 2

HCID 1140Toluene용매HCID 8028Tetrahydrofuran용매

실험 절차

Oxalyl chloride (2.23 mL, 25.9 mmol) was added to an ice-cold solution of 2-phenylindolizine (4.0 g, 20.7 mmol) in a mixture of toluene (40 mL) and THF (8 mL). The reaction mixture was stirred at r.t. for 5 h then concentrated in vacuo. The residue obtained was recrystallised from DCM-hexane to yield oxo-(2-phenyl-indolizin-3-yl)-acetyl chloride (4.6 g, 80%) as a solid.

후처리

  1. concentrationthen concentrated in vacuo
  2. customThe residue obtained
  3. customwas recrystallised from DCM-hexane

출처 및 근거

ORD 기록
ord-89f85fc6af424f4593ad5e01c930841e
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08604029B2

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