Formamidine acetate → HCID 178518231, 화합물
반응식
[NH2:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]([O:9]CC)=O.C(O)(=O)C.[CH:16](N)=[NH:17]>CCO>[CH:5]1[N:4]=[C:3]2[C:7]([N:17]=[CH:16][NH:1][N:2]2[CH:6]=1)=[O:9]참가 물질
4
실험 절차
A mixture of ethyl 1-amino-1H-imidazole-2-carboxylate (C-4) (800 mg, 5.16 mmol, 1.0 eq) and formamidine acetate (2.68 g, 25.78 mmol, 5.0 eq) in EtOH (100 mL) is stirred at reflux overnight. The resulting mixture is cooled to RT. The solid is collected by filtration, rinsed with EtOH (3×2 mL) and petroleum ether (2 mL×3), and then dried in vacuo to afford the product, imidazo[1,2-f][1,2,4]triazin-4-ol (C-5).
후처리
- temperatureat reflux overnight
- filtrationThe solid is collected by filtration
- washrinsed with EtOH (3×2 mL) and petroleum ether (2 mL×3)
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-1dae880d81a544f488751c7688749de1
- 출처 데이터셋
- uspto-grants-2013_12
- 특허 번호
- US08604032B2
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