Acetic Acid → HCID 66894508, 화합물

HRID 19110

반응식

HRID 19110 반응식
[CH2:1]([O:3][C:4]1[C:5]([F:13])=[C:6](B(O)O)[CH:7]=[CH:8][CH:9]=1)[CH3:2].C(O)(=[O:16])C.OO>O1CCCC1>[CH2:1]([O:3][C:4]1[C:5]([F:13])=[C:6]([OH:16])[CH:7]=[CH:8][CH:9]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 162177593-Ethoxy-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)

생성물 1

HCID 66894508HCID 66894508, 화합물수율 71%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3-ethoxy-2-fluoro-phenylboronic acid (10.0 g, 0.054 mol) in tetrahydrofuran (150 mL) was added glacial acetic acid (60 mL). The resulting mixture was cooled to 0° C. before hydrogen peroxide (50% aqueous solution, 8 mL) was added. The resulting mixture was allowed to come to room temperature and stirred for 23 h. The mixture was evaporated and the residue was dissolved in ethyl acetate, washed with hydrochloric acid (0.5N), water and brine. The organic phase was dried, filtered and evaporated to give 3-ethoxy-2-fluoro-phenol (6.00 g, 71%) as a brown oil.

후처리

  1. additionwas added
  2. customto come to room temperature
  3. customThe mixture was evaporated
  4. dissolutionthe residue was dissolved in ethyl acetate
  5. washwashed with hydrochloric acid (0.5N), water and brine
  6. customThe organic phase was dried
  7. filtrationfiltered
  8. customevaporated

출처 및 근거

ORD 기록
ord-7adf2dfca726471ca42cb65a1100631d
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741327B2

연결된 노트

불러오는 중…