Methylamine → 1269615-30-6

HRID 1911844노트

반응식

HRID 1911844 반응식
Cl[CH2:2][C:3]1[N:4]=[N:5][N:6]([CH3:8])[N:7]=1.[CH3:9][NH2:10]>>[CH3:9][NH:10][CH2:2][C:3]1[N:4]=[N:5][N:6]([CH3:8])[N:7]=1

참가 물질

3

반응물 2

HCID 6329MethylamineHCID 122050815-chloromethyl-2-methyl-2H-tetrazole

생성물 1

HCID 670586961269615-30-6

반응 조건

온도
45 °C

실험 절차

To 5-(chloromethyl)-2-methyl-2H-tetrazole (136.8 mg, 1.032 mmol), was added methylamine (4.00 mL of 2M solution in THF, 8.00 mmol). This was stirred for 16 hours at 45° C. A white precipitate formed in the reaction and it was allowed to continue stirring for another 24 hours at room temperature before being concentrated in vacuo and successively azeotroped with THF, triethylamine, methanol, and then DCM. 1H NMR (600 MHz, CDCl3) δ 2.23 (s, 3H), 3.80 (s, 2H), 4.29 (s, 3H).

후처리

  1. customA white precipitate formed in the reaction and it
  2. stirringto continue stirring for another 24 hours at room temperature
  3. concentrationbefore being concentrated in vacuo
  4. customsuccessively azeotroped with THF, triethylamine, methanol

출처 및 근거

ORD 기록
ord-0bcd22bebf4d40928a69a85fd30ac9f7
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08604038B2

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