(S,E)-tert-butyl 4-(4-(methylsulfonyl)-2-aminobut-3-en-1-yl)benzylcarbamate → (S,E)-tert-butyl (5-amino-7-(methylsulfonyl)hept-6-en-1-yl)carbamate

HRID 1912369노트

반응식

HRID 1912369 반응식
C([NH:20][C@H:21](/[CH:34]=[CH:35]/[S:36]([CH3:39])(=[O:38])=[O:37])[CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30])(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.CS(/C=C/[C@@H](N)CC1C=CC(CNC(=O)OC(C)(C)C)=CC=1)(=O)=O>>[NH2:20][C@H:21](/[CH:34]=[CH:35]/[S:36]([CH3:39])(=[O:38])=[O:37])[CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30]

참가 물질

3

반응물 2

HCID 71562244(S,E)-tert-butyl 4-(4-(methylsulfonyl)-2-aminobut-3-en-1-yl)benzylcarbamateHCID 86681599(S,E)-tert-butyl (5-(trityl-amino)-7-(methylsulfonyl)hept-6-en-1-yl)carbamate

생성물 1

HCID 86681598(S,E)-tert-butyl (5-amino-7-(methylsulfonyl)hept-6-en-1-yl)carbamate

실험 절차

This compound was prepared from trityl protected amine 73 in a synthetic procedure similar to that for compound 18. The purity was checked by LC-MS analysis and the amine was subjected to the next step without further purification.

후처리

  1. customThis compound was prepared from trityl
  2. customthe amine was subjected to the next step without further purification

출처 및 근거

ORD 기록
ord-f5fe96721dad4745ad55a31604d810b3
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609610B2

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