1,4-Dioxane hydrochloride → 3,3-Difluoro-1,6-diazaspiro[3,4]octane
반응식
C(OC([N:8]1[CH2:17][CH2:16][C:10]2([NH:13][CH2:12][C:11]2([F:15])[F:14])[CH2:9]1)=O)(C)(C)C.Cl.O1CCOCC1.Cl.CO>C(OCC)(=O)C>[F:14][C:11]1([F:15])[C:10]2([CH2:16][CH2:17][NH:8][CH2:9]2)[NH:13][CH2:12]1참가 물질
5
실험 절차
To an optically-active compound of 3,3-difluoro-1,6-diazaspiro[3,4]octane-6-carboxylic acid tert-butyl ester (211 mg) were added 4M hydrochloric acid-1,4-dioxane (2.1 ml) and 2M hydrochloric acid-methanol (2.1 ml), and the mixture was stirred at room temperature for 45 minutes. To the reaction mixture was added ethyl acetate, and the mixture was filtered to give the titled compound (163 mg).
후처리
- filtrationthe mixture was filtered
출처 및 근거
- ORD 기록
- ord-942dc82627814c0095355308d8c14c86
- 출처 데이터셋
- uspto-grants-2013_12
- 특허 번호
- US08609647B2
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