Thionyl Chloride → HCID 86665150, 화합물

HRID 1912510노트

반응식

HRID 1912510 반응식
[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10](O)=[O:11].S(Cl)([Cl:16])=O>CN(C)C=O>[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10]([Cl:16])=[O:11]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 671611162-((1S,2S,5S)-6,6-Dimethylbicyclo[3.1.1]heptan-2-yl)acetic acid

생성물 1

HCID 86665150HCID 86665150, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
22 °C

실험 절차

To a mixture of Example 1B (300 mg, 1.65 mmol) and thionyl chloride (901 μL, 12.4 mmol) was added a drop of dimethylformamide. The reaction was stirred at about 22° C. for 2 hours. The excess thionyl chloride was evaporated and the residue was dried under vacuum to afford the title compound.

후처리

  1. customThe excess thionyl chloride was evaporated
  2. customthe residue was dried under vacuum

출처 및 근거

ORD 기록
ord-4406a30cc25e48f1883537dfb684f406
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609674B2

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