Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(4-Nitro-2-(trifluoromethyl)phenylethynyl)pyridine → 4-(2-Pyridin-4-yl-ethyl)-3-(trifluoromethyl)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(4-Nitro-2-(trifluoromethyl)phenylethynyl)pyridine | HCID 23155274 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | HCID 178418390 | HCID 178418390 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-(2-Pyridin-4-yl-ethyl)-3-(trifluoromethyl)aniline | HCID 23155177 | 85% |
반응 단계
In 20 mL of ethanol, 1.3 g (4.45 mmol) of 4-(4-nitro-2-(trifluoromethyl)phenylethynyl)pyridine was dissolved and stirred on 100 mg of 10% palladium carbon overnight at room temperature in a hydrogen atmosphere. The catalyst was removed by filtration and the filtrate was concentrated and the residue was purified by a silica gel column (n-hexane:ethyl acetate=1:2) to obtain 1.0 g (85%) of a target product as a pale yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08609656B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-22078ad930e2479e9260fca9fb639d29 |
| 출처 메모 | uspto-grants-2013_12 |