Thionyl Chloride → HCID 86665150, 화합물

HRID 1912894노트

반응식

HRID 1912894 반응식
[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10](O)=[O:11].S(Cl)([Cl:16])=O>CN(C)C=O>[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10]([Cl:16])=[O:11]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 671611162-((1S,2S,5S)-6,6-Dimethylbicyclo[3.1.1]heptan-2-yl)acetic acid

생성물 1

HCID 86665150HCID 86665150, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
22 °C

실험 절차

To a mixture of the product from Example 4B (300 mg, 1.65 mmol) and thionyl chloride (901 μL, 12.4 mmol) was added a drop of dimethylformamide. The reaction was stirred at 22° C. for 2 hours. The excess of thionyl chloride was evaporated and the residue was dried under vacuum to afford the title compound.

후처리

  1. customThe excess of thionyl chloride was evaporated
  2. customthe residue was dried under vacuum

출처 및 근거

ORD 기록
ord-725e7c30827546548599d3f286001c5d
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609669B2

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