3,3-Dimethylbutanoyl chloride → N-(3-tert-butylpyrazolo[1,5-a]pyrimidin-2-yl)-3,3-dimethylbutanamide
반응식
[C:1]([C:5]1[C:6]([NH2:14])=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:3])[CH3:2].[CH3:15][C:16]([CH3:22])([CH3:21])[CH2:17][C:18](Cl)=[O:19]>>[C:1]([C:5]1[C:6]([NH:14][C:18](=[O:19])[CH2:17][C:16]([CH3:22])([CH3:21])[CH3:15])=[N:7][N:8]2[CH:13]=[CH:12][CH:11]=[N:10][C:9]=12)([CH3:4])([CH3:2])[CH3:3]참가 물질
3
실험 절차
The product from Example 105B and 3,3-dimethylbutanoyl chloride were processed using the method analogous to that described in Example 105C to afford the title compound. 1H NMR (300 MHz, DMSO-d6): δ ppm 1.05 (s, 9H), 1.45 (s, 9H), 2.20 (s, 2H), 6.99 (dd, J=7.1, 4.1 Hz, 1H), 8.47 (dd, J=4.1, 1.7 Hz, 1H), 8.94 (dd, J=7.0, 1.9 Hz, 1H), 9.59 (br s, 1H); MS (DCI) m/z 289 (M+H)+.
출처 및 근거
- ORD 기록
- ord-0f2b216d79654e18a00c129bbbd62949
- 출처 데이터셋
- uspto-grants-2013_12