Thionyl Chloride → HCID 86665181, 화합물

HRID 1912947노트

반응식

HRID 1912947 반응식
[CH:1]1([S:6][CH2:7][C:8]([OH:10])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:13])=O>>[CH:1]1([S:6][CH2:7][C:8]([Cl:13])=[O:10])[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 15728315(Cyclopentylsulfanyl)acetic acid

생성물 1

HCID 86665181HCID 86665181, 화합물

반응 조건

온도
70 °C

실험 절차

The product from Example 143B (6.56 g) was combined with thionyl chloride (50 mL, 685 mmol) and the reaction mixture was heated at 70° C. for 2 hours. The reaction mixture was concentrated under vacuum, and the residue was dissolved in CHCl3 (50 mL) and concentrated again to remove excess thionyl chloride. The residue was distilled under vacuum (air bath 100-110° C./˜10 mm) to provide the title compound, used directly for the next step.

후처리

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. dissolutionthe residue was dissolved in CHCl3 (50 mL)
  3. concentrationconcentrated again
  4. customto remove excess thionyl chloride
  5. distillationThe residue was distilled under vacuum (air bath 100-110° C./˜10 mm)

출처 및 근거

ORD 기록
ord-ba22d4f86d254542b5d9526c68ae0697
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609669B2

반응 노트

불러오는 중…