3,3-Dimethyl-1-butenylboronic acid → HCID 68752051, 화합물

HRID 1912948노트

반응식

HRID 1912948 반응식
[CH3:1][C:2]([CH3:9])([CH3:8])[CH:3]=[CH:4]B(O)O.[CH3:10][C:11]([CH3:32])([CH3:31])[CH2:12][C:13]([NH:15][C:16]1[C:24](C2C=NC=CC=2)=[C:19]2[N:20]=[CH:21][CH:22]=[CH:23][N:18]2[N:17]=1)=[O:14]>>[CH3:1][C:2]([CH3:9])([CH3:8])/[CH:3]=[CH:4]/[C:24]1[C:16]([NH:15][C:13](=[O:14])[CH2:12][C:11]([CH3:31])([CH3:10])[CH3:32])=[N:17][N:18]2[CH:23]=[CH:22][CH:21]=[N:20][C:19]=12

참가 물질

3

반응물 2

HCID 27632983,3-Dimethyl-1-butenylboronic acidHCID 687511603,3-dimethyl-N-[3-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-2-yl]butanamide

생성물 1

HCID 68752051HCID 68752051, 화합물

실험 절차

3,3-Dimethyl-1-butenylboronic acid (Aalenchem) and the product from Example 110B were processed using the method analogous to that described in Example 110C to provide the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 10.03-10.05 (bs, 1H), 9.00 (dd, J=6.9, 1.7 Hz, 1H), 8.57 (dd, J=4.1, 1.7 Hz, 1H), 7.03 (dd, J=6.9, 4.1 Hz, 1H), 6.75 (d, J=16.3 Hz, 1H), 6.23 (d, J=16.3 Hz, 1H), 2.26 (s, 2H), 1.09 (s, 9H), 1.07 (s, 9H); MS (ESI) m/z 315 (M+H)+.

출처 및 근거

ORD 기록
ord-791790233c89419b98e11d91535a1acc
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609669B2

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