(+/-)-ethyl 2-(1-methyl-2,3-dihydro-1H-inden-1-yl)acetate → ethyl 2-(2,3-dihydro-1H-inden-1-yl)acetate

HRID 1912970노트

반응식

HRID 1912970 반응식
C[C:2]1([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1>CCO.[Pd]>[CH:2]1([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1

참가 물질

4

반응물 1

HCID 86665180(+/-)-ethyl 2-(1-methyl-2,3-dihydro-1H-inden-1-yl)acetate

생성물 1

HCID 12322855ethyl 2-(2,3-dihydro-1H-inden-1-yl)acetate수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a mixture of products from Example 131A (0.47 g, 2.3 mmol) in EtOH (20 mL) was added Pd/C (49.5 mg, 0.046 mmol). The reaction mixture was stirred under H2 atmosphere using a balloon until the starting material completely consumed. The mixture was filtered and concentrated under reduced pressure to obtain 0.47 g of the title compound. MS (DCI/NH3) m/z 222 (M+NH4)+.

후처리

  1. customcompletely consumed
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-eed5562249a14ebfab76c882ef6eb241
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609669B2

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