1-(Tetrahydro-2H-pyran-4-YL)-1H-pyrazol-4-amine → HCID 59199121, 화합물

HRID 1913104노트

반응식

HRID 1913104 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]3[N:11]([N:15]=[C:16]([NH:18][C:19]4[CH:20]=[N:21][N:22]([CH2:24][C@H:25](O)[CH3:26])[CH:23]=4)[N:17]=3)[CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1.[O:28]1CCC(N2C=C(N)C=N2)[CH2:30][CH2:29]1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:10]3[N:11]([N:15]=[C:16]([NH:18][C:19]4[CH:20]=[N:21][N:22]([CH:24]5[CH2:25][CH2:26][O:28][CH2:29][CH2:30]5)[CH:23]=4)[N:17]=3)[CH:12]=[CH:13][CH:14]=2)=[CH:7][CH:8]=1

참가 물질

3

반응물 2

HCID 510637031-(Tetrahydro-2H-pyran-4-YL)-1H-pyrazol-4-amineHCID 59199014(R)-1-(4-(8-(4-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1H-pyrazol-1-yl)propan-2-ol

생성물 1

HCID 59199121HCID 59199121, 화합물

실험 절차

Made by following the procedure described for the preparation of (R)-1-(4-(8-(4-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1H-pyrazol-1-yl)propan-2-ol with 1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine and making non-critical variations. 1H NMR (400 MHz, DMSO-d6) δ 9.31 (s, 1H), 8.64 (dd, J=6.6, 0.9 Hz, 1 H), 8.14 (d, J=8.9 Hz, 2 H), 7.87 (s, 1 H), 7.73 (m, 1 H), 7.50 (s, 1 H), 7.08 (d, J=8.9 Hz, 3 H), 4.35 (m, 1 H), 3.98 (dd, J=13.4, 10.9 Hz, 2 H), 3.83 (s, 3 H), 3.47 (m, 2 H), 1.93 (m, 4 H).

출처 및 근거

ORD 기록
ord-21dee13d65a14ad5bd37a60270ee9589
출처 데이터셋
uspto-grants-2013_12
특허 번호
US08609687B2

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