Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cesium carbonate → 6-Fluoro-2-[(4-methoxyphenyl)methyl]isoquinolin-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| 반응물 | 6-Fluoroisoquinolin-1(2H)-one | HCID 45090802 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 6-Fluoro-2-[(4-methoxyphenyl)methyl]isoquinolin-1-one | HCID 59818260 | 93.7% |
반응 단계
169 μL of p-methoxybenzylchloride (1.24 mmol, 1.1 eq) were added to a suspension of 200 mg of 6-fluoro-isoquinolinone (176) (1.13 mmol) and 368 mg of Cs2CO3 (1.36 mmol, 1.2 eq) in 3 mL of DMF. The mixture was stirred for 2 h and then poured on ice. The precipitate was filtered, washed with water and dried to yield 300 mg of the title compound. LCMS Method B, retention time 1.76 min, detected mass 284.14 [M+H]+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08609691B2 |
| 출처 데이터셋 | uspto-grants-2013_12 |
| ORD ID | ord-51c4be5eb72648b18814ce9e96212d8e |
| 출처 메모 | uspto-grants-2013_12 |