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3,4-Diaminopyridine → biphenyl-4-yl[4-(1H-imidazo[4,5-c]pyridin-2-yl)piperidin-1-yl]methanone

HRID 1913159
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HRID 1913159 반응식
[C:1]1([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:6]=[CH:5][C:4]([C:7]([N:9]2[CH2:14][CH2:13][CH:12]([C:15](O)=O)[CH2:11][CH2:10]2)=[O:8])=[CH:3][CH:2]=1.[NH2:24][C:25]1[CH:26]=[N:27][CH:28]=[CH:29][C:30]=1[NH2:31].P(OC1C=CC=CC=1)(OC1C=CC=CC=1)(OC1C=CC=CC=1)=O>N1C=CC=CC=1>[C:1]1([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:6]=[CH:5][C:4]([C:7]([N:9]2[CH2:14][CH2:13][CH:12]([C:15]3[NH:31][C:30]4[CH:29]=[CH:28][N:27]=[CH:26][C:25]=4[N:24]=3)[CH2:11][CH2:10]2)=[O:8])=[CH:3][CH:2]=1
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참가 물질

5

반응물 3

HCID 59183,4-DiaminopyridineHCID 8289Triphenyl PhosphateHCID 8930531-([1,1'-Biphenyl]-4-carbonyl)piperidine-4-carboxylic acid

생성물 1

HCID 178519408biphenyl-4-yl[4-(1H-imidazo[4,5-c]pyridin-2-yl)piperidin-1-yl]methanone수율 27.8%

시약·촉매·용매 1

HCID 1049Pyridine용매

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온도
120 °C

실험 절차

To a mixture of 1-(biphenyl-4-ylcarbonyl)piperidine-4-carboxylic acid (0.10 g, 0.32 mmol) and 3,4-diaminopyridine (35 mg, 0.32 mmol) in pyridine (1 mL) is added triphenyl phosphate (0.10 mL, 0.38 mmol). The mixture is heated under microwave irradiation at 120° C. for 50 mins. Purification by preparative HPLC gives 34 mg of biphenyl-4-yl[4-(1H-imidazo[4,5-c]pyridin-2-yl)piperidin-1-yl]methanone.

후처리

  1. customPurification by preparative HPLC

출처 및 근거

ORD 기록
ord-372b6ab6863c4d32aaf284a40ee14b9c
출처 데이터셋
uspto-grants-2013_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08609696B2

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